Molecular Characteristics of Canine Cardiac Myosin
نویسندگان
چکیده
منابع مشابه
Molecular Characteristics of Canine Cardiac Myosin.
• Contraction of the heart is dependent upon the proteins myosin and actin. Studies of these contractile proteins have therefore been of interest in the understanding of the normal contractile process, and attempts have been made to relate the diminished cardiac contraction observed in congestive heart failure to alterations in the myosin molecule. Cardiac myosin has been prepared generally by ...
متن کاملCanine cardiac myosin with special reference to pressure overload cardiac hypertrophy. II. Myosin ATPase.
Normal canine cardiac myosin exhibits Ca”+ATPase of 0.13 pmol of Pi/min*mg and (K+,EDTA)-ATPase of 0.47 pm01 of Pi/min*mg. Specific activities are similar in myosin preparations from normal left and right ventricles, contrary to the prior report by Wikman-Coffelt et al. (Wikman-Coffelt, J., Fenner, C., Smith, A., and Mason, D. T. (1975) J. Biol. Chem. 250,1257-1262). At 5 weeks after aortic ban...
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Two myosin isoforms are expressed in myocardium, alphaalpha-homodimers (V(1)) and betabeta-homodimers (V(3)). V(1) exhibits higher velocities and myofibrillar ATPase activities compared with V(3). We also observed this for cardiac myosin from normal (V(1)) and propylthiouracil-treated (V(3)) mice. Actin velocity in a motility assay (V(actin)) over V(1) myosin was twice that of V(3) as was the m...
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Previous studies have suggested that the molecular and enzymatic parameters of cardiac myosin are quite similar to those of its skeletal counterpart (I). Thus, the weight average molecular weight, iWW, weight intrinsic viscosity, [v], and intrinsic sedimentation constant, siO, W, are comparable with the corresponding data on the skeletal protein (2). Also, the enzymatic adenosine triphosphatase...
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The essential myosin light chain (ELC) is involved in modulation of force generation of myosin motors and cardiac contraction, while its mechanism of action remains elusive. We hypothesized that ELC could modulate myosin stiffness which subsequently determines its force production and cardiac contraction. Therefore, we generated heterologous transgenic mouse (TgM) strains with cardiomyocyte-spe...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1965
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.16.1.74